Principal Investigator in Musculoskeletal Regenerative Medicine

Sinai Health, Lunenfeld-Tanenbaum Research Institute logoLocation: Toronto, ON, Canada

Position Type: Faculty

Position URL:



The Lunenfeld-Tanenbaum Research Institute of Sinai Health, a University of Toronto-affiliated biomedical research center, is recruiting an emerging leader in the area of Musculoskeletal Regenerative Medicine. The appointment is for Principal Investigator, either basic scientist or clinician-scientist, at the academic rank of Assistant Professor. We seek applicants that aim to develop outstanding independent research programs at the cutting edge of musculoskeletal development, maintenance and regeneration. These include, but are not limited to, stem cell biology, cell/tissue engineering, and animal models, with applications to tissue trauma and human disease using approaches such as molecular “omics”, single-cell analytics, and/or high resolution imaging. Applicants with combined computational and wet lab focus are also encouraged to apply.

The successful candidate will join the Lunenfeld-Tanenbaum Research Institute’s faculty as the inaugural holder of the Tanenbaum Chair in Musculoskeletal Regenerative Medicine at Sinai Health and the University of Toronto. The Lunenfeld-Tanenbaum Research Institute is internationally renowned for its basic and applied research in stem cell biology, systems biology, diabetes, cancer, neurobiology, musculoskeletal regenerative medicine, and women’s and infants’ health. The Institute is committed to excellence in health research and the training of young investigators and provides a collaborative research-intensive environment with modern and innovative core facilities housed in the Network Biology Collaborative Centre that includes proteomics, single-cell and spatial genomics, robotics, and the Nikon Centre of Excellence in cell imaging. Sinai Health System is also home to The Centre for Phenogenomics, a state-of-the-art facility for mouse models, and is a founding member of the Nanoscale Biomedical Imaging Facility. Close ties with flagship clinical programs, as well as a history of biotech entrepreneurship, ensure the successful translation of our research findings.

The successful candidate will be cross-appointed to appropriate research and/or clinical department(s) at the University of Toronto, and will be affiliated with the University-based Tanenbaum Institute for Science in Sport. The University of Toronto has one of the world’s most concentrated and largest biomedical research communities that includes 9 affiliated academic hospital research institutes.

Toronto is a vibrant, safe, multicultural city with excellent quality of life.



Investigators at the Lunenfeld-Tanenbaum Research Institute are appointed to independent positions equivalent to Assistant, Associate or Full Professor, depending on experience; preference for this opportunity will be given to individuals qualifying at the level of Assistant Professor. The successful candidate will be expected to initiate and lead innovative, independent, and externally funded, research programs of the highest international calibre and impact. Collaborations within the research Institute and clinical departments are also encouraged. Successful candidates will have opportunities for career growth and advancement through the ranks, and we offer competitive, generous salaries and start-up packages commensurate with experience and qualifications.

Successful candidates will hold a PhD and/or MD degree, with postdoctoral experience and an established record of research accomplishment as demonstrated by outstanding publications, presentations at international conferences, awards and accolades, and reference letters. The Lunenfeld-Tanenbaum Research Institute and Sinai Health System recognize that scholars have varying career paths and that career interruptions due to personal circumstances can be part of an excellent academic record. Candidates are encouraged to explain any personal circumstances in order to allow for a fair assessment of their application. The committee will carefully consider any impact of career interruptions in their decision-making.

The Lunenfeld-Tanenbaum Research Institute and Sinai Health are strongly committed to diversity within their community and especially welcome applications from racialized persons / persons of colour, women, Indigenous / Aboriginal People of North America, persons with disabilities, and members of sexual minority groups, and others who may contribute to the further diversification. As part of the University of Toronto and Sinai Heath System’s implementation of their Canada Research Chairs Equity, Diversity & Inclusion Action Plan, the successful candidate in this search may be eligible for nomination for a CRC Tier 2 Chair if they self-identify as a member of the following federally designated groups, as defined by the Employment Equity Act (women, visible minorities, persons with disabilities, and Indigenous Peoples), or as trans, non-binary, or Two-Spirit. The nominee’s research area must align with the subject matter eligibility of CIHR. Tier 2 Chairs are intended for exceptional emerging scholars. Nominees should be within ten years of receiving their PhD or MD degree (not including career breaks, such as maternity, parental or extended sick leave, clinical training, etc.). Applicants who are more than 10 years from having earned their highest degree (and where career breaks exist, such as maternity, parental or extended sick leave, clinical training, etc.) may have their eligibility for a Tier 2 chair assessed through the program’s Tier 2 justification process. For further information on the federally endowed Canada Research Chairs Program, open to all nationalities, including eligibility criteria, please consult the Canada Research Chairs website. For more information about the CRC nomination process at the University of Toronto, contact Judith Chadwick, Assistant Vice-President, Research Services, at

Application Instructions

Applications should include:

  1. A one-page structured summary that includes: A) a brief education/training history; B) a summary of the applicant’s most important research contributions (up to five), and C) an abstract of the research plan.
  2. A cover letter.
  3. A research statement highlighting the proposed research program (not exceeding 3 pages, including figures).
  4. A statement highlighting past and future commitment to EDI (0.5 to 1 page). Please identify your strengths and experiences in increasing EDI in your previous institutional environments and in supporting diverse trainees and co-workers in the future.
  5. A complete curriculum vitae.
  6. Three reference letters.

Applications should be submitted via the Interfolio website prior to Dec 1st, 2023.


Applicants needing additional information can contact Dr. Jeff Wrana at

NOTE: E-mailed applications will not be accepted.