We are looking for a highly motivated post-doctoral fellow in chemical proteomics to join the laboratory of Anne-Claude Gingras at the Lunenfeld-Tanenbaum Research Institute (https://gingraslab.lunenfeld.ca/). Dr. Gingras specializes in the study of protein complexes and subcellular proteome organization, combining cutting edge mass spectrometry-based approaches with modern cell and molecular biology techniques. She has developed multiple experimental and computational approaches (many through collaborative efforts) to confidently identify and quantify interaction partners for proteins of interest, and has co-developed a number of widely used software tools to assist in this process. She has applied these powerful systematic approaches to a number of protein classes (e.g. phosphatases, bromodomain-containing proteins, RNA-binding proteins) to accelerate discovery, and is ultimately interested in gaining deep biological insight into the mechanisms of disease.
The post-doctoral fellow will join her multi-disciplinary team and have the opportunity to extend chemical proteomics capabilities in pre-clinical drug discovery and structural proteomics. S/he will develop and optimize new methodologies for drug target identification, protein complex composition and protein cross-linking for structural analysis by mass spectrometry, and apply these approaches to the study of signaling molecules.
The Gingras lab is part of the Lunenfeld-Tanenbaum Research Institute’s Molecular, Cell and Systems Biology group whose faculty members are internationally renowned for their work in signalling networks, cancer and developmental biology, structural biology, imaging, high- throughput screening and proteomics. With numerous discoveries in basic and applied research in cancer, developmental biology, stem cell biology, diabetes, genetic disorders and women’s and infants’ health, the Lunenfeld-Tanenbaum Research Institute is committed to excellence in health research and the training of young investigators. The Institute provides a research-intensive environment with modern and innovative core facilities that include robotics, proteomics and imaging that drive technology development (Genome Canada Funded Network Biology Collaborative Centre, NBCC; http://nbcc.lunenfeld.ca/). The selected postdoctoral fellow will work with colleagues in the proteomics group of the NBCC to develop and apply new approaches.
Lunenfeld-Tanenbaum Research Institute labs engage in productive collaborations within the Institute, Sinai Health System, the larger University of Toronto community, and beyond. The University of Toronto has one of the most concentrated biomedical research communities in the world, including 9 academic hospital research institutes that are fully affiliated with the University. Dr. Gingras is a Professor in the Department of Molecular Genetics at the University (http://www.moleculargenetics.utoronto.ca/).
Applicants should have a Ph.D. in biological chemistry, biochemistry, organic chemistry, or bioanalytical chemistry, with a strong publication record. Demonstrated proficiency in biochemistry (protein purification, enzymatic assays), chemistry (organic chemistry, click-chemistry, cross-linking), proteomics (quantitative mass spectrometry, analysis of post-translational modifications) and/or bioinformatics is required. The applicants must possess exceptional communication skills (verbal, written and presentation) and be comfortable engaging and exchanging information with other members of the laboratory and collaborators.
Please apply directly at Interfolio: https://apply.interfolio.com/66200