A postdoctoral position in the neurobiology of Parkinson’s disease is available in the laboratory of Dr. Scott Ryan at the University of Calgary. The Ryan Lab investigates Parkinson’s disease using cutting-edge patient-derived stem cell models (2D and 3D), alongside animal models infused with toxic oligomers. This project will explore how alpha-synuclein fibrils drive cellular pathology, with a particular focus on whether distinct amyloid structural strains drive unique patterns of neural dysfunction.
As part of our multidisciplinary team, the successful candidate will integrate stem cell technology with advanced biophysical approaches to examine the effects of pathogenic fibrils on synaptic architecture, endosomal trafficking, autophagy, and nuclear function. Our overarching goal is to identify the molecular mechanisms that accelerate disease progression and leverage this knowledge toward therapeutic development.
Qualifications
- Ph.D. in Neuroscience, Biochemistry, or a related discipline
- Established track record of publications
- Highly organized and detail-oriented
- Strong time-management skills and the ability to work independently
Technical Skills You Will Develop
- hESC/hiPSC culture and maintenance
- Directed differentiation and organoid culture
- Advanced light microscopy
- In vivo imaging
- Protein biochemistry
Salary & Benefits
- Salary will be consistent with the current CIHR recommendations
- Benefits University of Calgary Postdoctoral Associates can be found here https://www.ucalgary.ca/hr/benefits-pension/group-benefits/postdocs
How to Apply:
Please send your Cover letter, CV, and contact information for three professional/academic references to scott.ryan@ucalgary.ca. Applications will be reviewed on a rolling basis until the position is filled.
Learn more about our research at: www.neurobiology.ca
