2019 Program

PROGRAMME FINAL | FINAL PROGRAM

DIMANCHE 2 JUIN | SUNDAY JUNE 2, 2019

12:00 –

Accueil des participants Welcome of participants

13:00 – 14:20

 Atelier I – Équité, diversité et inclusion – Salle S1-151|
Workshop I – Equity, Diversity and Inclusion – Room S1-151

Modératrice | Moderator: Katherine Borden [IRIC, Université de Montréal]
Ève Langelier
 [Université de Sherbrooke], Chaire pour les femmes en sciences et en génie au Québec |
Chair for Women in Science and Engineering in Quebec
Imogen Coe [Ryerson University] Michael Hendricks [McGill University] Roxane de la Sablonnière [Université de Montréal]

14:20 – 15:50

 Atelier II – Science & société – Salle S1-151|
Workshop II – Science & Society – Room S1-151
Modérateur | Moderator: Tarik Möröy [Institut de recherches cliniques de Montréal] Mona Nemer, Conseillère scientifique en chef du Canada | Chief Science Advisor of Canada
Marie Franquin, Co-présidente | Co-President, Science & Policy Exchange
Éric Racine [Institut de recherches cliniques de Montréal]

15:50 – 16:00

 Pause | Break

16:00 – 16:10

 Mot de bienvenue – Salle S1-151 | Welcome address – Room S1-151
Tarik Möröy, Président de la SCBM | CSMB President

16:10 – 17:30

 Présentations par des récipiendaires de prix – Salle S1-151 |
Talks by Awardees – Room S1-151
Jonathan Schertzer
 [McMaster University], récipiendaire du prix "Nouveau scientifique" | "New Investigator" Awardee
Glucose symbiosis between microbiota and host
Anne-Claude Gingras [LTRI, University of Toronto], récipiendaire du prix "Conférence d’honneur Jeanne Manery Fisher" |
"Jeanne Manery Fisher Memorial Lecture" Awardee
A proximity map of a human cell 

17:30 – 17:45

 Pause | Break

17:45 – 18:45

 Conférence d’ouverture – Salle S1-151 | Keynote Lecture – Room S1-151
Helen McNeill [Washington University in St. Louis] Coordinating tissue growth and organization

18:45 – 21:00

 Cocktail de réseautage | Networking Cocktail

 

LUNDI 3 JUIN 2019 | MONDAY JUNE 3, 2019

8:30 – 10:15

 Session I – A: Levures I – Salle S1-111Yeast I – Room S1-111
Modérateur | Moderator: Hugo Wurtele
Jennifer Cobb 
[University of Calgary] Dyskerin in yeast contributes to checkpoint activation and DNA repair at a DSB
Phil Hieter [University of British Columbia] Setting a trap for cancer cells: Screening with catalytically inactive mutations to discover new synthetic lethality-based
therapeutic targets

Kin Chan [University of Ottawa] The pattern of mutations induced by metabolic processes in yeast closely resembles mutational signature 5 in cancers
Larasati [University of Waterloo] Characterization of the Rif1-Dbf4 interaction in Saccharomyces cerevisiae
Rodrigo Reyes [McGill University] Subunit dynamics in the eukaryotic replisome in live cells

8:30 – 10:15

Session I – B: Modèles biochimiques et biophysiques – Salle S1-151| Biochemical & Biophysical Models – Room S1-151
Modératrice | Moderator: Katherine Borden
Yuh Min Chook
 [University of Texas Southwestern Medical Center] Karyopherins as chaperones
Julie Forman-Kay [Hospital for Sick Children, University of Toronto] Phase separation biophysics and implications for biological function
Kalle Gehring [McGill University] Cysteine phosphorylation in the PRL/CNNM pathway and cancer
Mohammadjavad Paydar [IRIC, Université de Montréal] Ternary complex of two bent tubulin heterodimers held head-to-tail by AMP-PNP-bound Kif2A provides molecular insight into
the action of Kinesin-13 at microtubule ends

Swati Singh [IRIC, Université de Montréal] Evolved plasticity of RAS family GTPase interactions with effector binding domains

10:15 – 10:45

 Pause Café | Coffee Break

10:45 – 12:30

Session II –A: Invertébrés I – Salle S1-151| Invertebrates I – Room S1-151
Modératrice | Moderator: Esther Verheyen
Julie Claycomb [University of Toronto] Understanding small RNA-mediated gene regulation through the lens of C. elegans Argonautes
Abigail Gerhold [McGill University] Mitosis in situ – how context shapes cell division
Ian Chin-Sang [Queen’s University] Identification of novel regulators of Insulin-like signaling and characterization of the 40 Insulin-like peptides in C. elegans
Damien Garrido [IRIC, Université de Montréal] The role of Cyclin B3 in anaphase onset in Drosophila
Eugénie Goupil [IRIC, Université de Montréal] Elucidating the role of OSGN-1 in Rho signalling in C. elegans

10:45 – 12:30

Session II –B: Levures II – Salle S1-111 | Yeast II – Room S1-111 Modératrice | Moderator: Lea Harrington
Sveta Makovets 
[University of Edinburgh] Using budding yeast to understand the population dynamics in cells with telomerase insufficiency
Hugo Wurtele [HMR, Université de Montréal] Sirtuin-mediated histone deacetylation promotes DNA replication in cells with short telomeres
Michael Downey [University of Ottawa] Polyphosphorylation as a new lysine PTM
Elizabeth Walden [University of Ottawa] Phenomic screen implicates the yeast lysine acetyltransferase NuA4 in regulation of glycogen synthesis and mitochondrial
morphology through the PKA inhibitor Bcy1

Vy Ngo [Western University] Novel crosstalk between the antioxidant and heat shock responses in cancer

12:30 – 14:00

 Dîner | Lunch

14:00 – 16:00

 Session présentations par affiches | Poster Session

16:00 – 17:45

Session III –A: Modèles murins I – Salle S1-151| Murine Models I – Room S1-151
Modératrice | Moderator: Anastasia Nijnik
Anastasia Nijnik [McGill University] MYSM1 Maintains Ribosomal Protein Gene Expression in Hematopoietic Stem Cells: Implications for the Human
MYSM1-Deficiency Syndrome

Pierre Priam [IRIC, Université de Montréal] SMARCD1 subunit of SWI/SNF complexes collaborates with E2A to promote lymphoid specification
Katie Teng [McGill University] Modeling High-grade serous ovarian carcinoma using in vivo oviduct electroporation, CRISPR/Cas9-mediated genome editing and lineage tracing
Chidalu Edechi [University of Manitoba] PIP overexpression in 4T1 cells slows down breast cancer progression in a transplantable mouse model
Jennifer Fraszczak [Institut de recherches cliniques de Montréal] GFI1/LSD1 complex is required to control inflammation in a specific monocyte population

16:00 – 17:45

 Session III –B: Biologie chimique – Salle S1-111| Chemical Biology – Room S1-111
Modératrice | Moderator: Julie Forman-Kay
Joelle Pelletier [Université de Montréal] Creating and exploiting drug resistance in classical DHFRs and inhibiting new ones
Ann English [Concordia University] Live-cell FLIM imaging of protein heme loading: the extraordinary case of cytochrome c peroxidase
FuiBoon Kai [University of California, San Francisco] Extracellular matrix dimensionality reduces cellular cortical tension to stimulate Arf6/Rac pro-survival signaling in mammary
epithelial cells

Dalia Barsyte-Lovejoy [University of Toronto] Chemical biology in epigenetics: from chemical tools in cancer models to clinical applications
Doris Schuetz [IRIC, Université de Montréal] Integrating interaction hotspots of the SOS/Ras complex to rationalize small molecule design

MARDI 4 JUIN 2019 | TUESDAY JUNE 4, 2019

8:30 – 10:15

Session IV –A: Modèles dérivés de patients – Salle S1-151 | Patient-derived Models – Room S1-151
Modératrice | Moderator: Kristin Hope
Ming-Sound Tsao 
[University of Toronto] New patient-derived models to study human lung cancer
Jennifer Chan [University of Calgary] The role of CIC loss and ETS de-repression in gliomagenesis
Thomas Milan [IRIC, Université de Montréal] Integrative epigenomic analysis to identify potential biomarkers in KMT2A translocated acute myeloid leukemia
Elena Kuzmin [McGill University] Evolution of large copy number variants in breast cancer through genetic network rewiring
Veronique Lisi [CUSM/ LDI] Single cell analysis of oncohistone mutation effect on transcriptional program in pediatric high-grade gliomas

8:30 – 10:15

Session IV –B: Modèles murins II – Salle S1-111| Murine Models II – Room S1-111
Modérateur | Moderator: Jean-François Côté
Josie Ursini-Siegel 
[LDI, McGill University] Novel therapeutic strategies to increase the clinical impact of biguanides in oncology
Daniel Schramek [LTRI, University of Toronto] In vivo veritas – using CRISPR to unearth novel cancer genes
Paola Marignani [Dalhousie University] Using CRISPR-Cas9 mouse model to study lung cancer
Marjorie Lapouge [IRIC, Université de Montréal] Myc as a downstream effector of Yes in hepatocarcinogenesis
Adam Golding [University of Guelph] Investigating the role of Nck cytoskeletal adaptors in mammary development and breast cancer

10:15 – 10:45

 Pause Café | Coffee Break

10:45 – 12:30

 Session V –A: Modèles d’hématopoïèse et d’immunité contre le cancer – Salle S1-111|
Models of Hematopoïesis and Cancer Immunity – Room S1-111

Modérateur | Moderator: André Veillette
André Veillette 
[Institut de recherches cliniques de Montréal] SLAM family receptors in immune cells
Kevin Bennewith [BC Cancer Agency Research Centre] Regulatory T cells in the lung microenvironment: implications for tumour growth in the lungs
Yeji An [Hospital for Sick Children] Cdh1 and Pik3ca mutations cooperate to induce Immune-Related Invasive Lobular Carcinoma of the breast
Julie Ross [Institut de recherches cliniques de Montréal] Deletion of the Miz-1 POZ domain increases efficacy of cytarabine treatment in T- and B-ALL/lymphoma mouse models
Morla Phan [University of Guelph] Effect of Rapamycin on Canine Mast Cell Cancer Cell DNA Damage Responses Following Radiation

10:45 – 12:30

 Session V –B: Modèles cellulaires et tissulaires – Room S1-151 | Cellular and Tissues Models – Room S1-151
Modérateur | Moderator: François Boudreau
François Boudreau 
[Université de Sherbrooke] A central role for the nuclear receptor HNF4alpha in the regulation of intestinal homeostasis
Marjorie Brand [OHRI, University of Ottawa] Understanding cell fate decisions in erythropoiesis using quantitative proteomics and single-cell mass cytometry
Lisa Julian [Ottawa Hospital Research Institute] A Multi-system Stem Cell Model of Tuberous Sclerosis Neoplasms Reveals Lineage-specific Proteostasis Signaling and
Therapeutic Sensitivities

Léo Aubert [IRIC, Université de Montréal] A surfaceome-based CRISPR/Cas9 screen reveals unexpected vulnerabilities in KRAS-addicted colorectal cancers
John Abousawan [Ryerson University] A switch in EGFR nanoscale organization upon HER2 co-expression defines unique signaling in breast cancer cells

12:30 – 14:00

 Dîner | Lunch

14:00 – 15:30

 Assemblée générale SCBM – Salle S1-111 | CSMB General Assembly – Room S1-111
Atelier III – planification carrière – Salle S1-151 | Workshop III – Career Planning – Room S1-151

Modératrice | Moderator: Marianne Chevrier
Claude Perreault,
Professeur titulaire |Full Professor, IRIC – Université de Montréal
Stephanie Weber, Professeure adjointe |Assistant Professor, McGill University
Michel Paré,
 Gestionnaire senior d’agents de liaison médicale, Novo Nordisk| Senior Manager MSLs, Novo Nordisk
Julie Lambert, Conseillère principale aux relations gouvernementales et institutionnelles | Senior Advisor, Government and
Institutional Relations, Université de Montréal
Martin Primeau, Journaliste/ recherchiste/ créateur de contenu/ rédacteur indépendant | Journalist/ Researcher/ Content
Creator/ Editor

15:30 – 17:15

 Session VI –A: Invertébrés II – Salle S1-151| Invertebrates II – Room S1-151
Modérateur | Moderator: Jean-Claude Labbé
Bob Goldstein 
[University of North Carolina at Chapel Hill] Tardigrades: an emerging model system for studying how life can survive extremes
Julie Brill [Hospital for Sick Children] Nuclear and perinuclear PIP2 signaling – lessons from Drosophila
Caroline Baril [IRIC, Université de Montréal] A genetic screen in Drosophila uncovers functional modulators of the NUP98-HOXA9 human oncoprotein
Kimberley Gauthier [McGill University] LIN-2/7/10 complex revisited: complex-independent function of LIN-10 (APBA) and LIN-7 (Veli) in EGFR signaling in C. elegans
Virginie Mondin [IRIC, Université de Montréal] A PTEN/PLC pathway reduces endosomal PI(4,5)P2 and can compensate for loss of the OCRL phosphatase

15:30 – 17:15

 Session VI –B: Modélisation par ordinateur – Salle S1-111 | Computational Modelling – Room S1-111
Modérateur | Moderator: Michelle Scott
Sébastien Lemieux 
[IRIC, Université de Montréal] A neural network-based approach to dimensionality reduction with applications in transcriptomics
Quaid Morris [University of Toronto] Reading the fossil record of a cancer
Guillaume Poirier-Morency [IRIC, Université de Montréal] miRBooking 2.0: an Enzymatic Model for the Microtargetome
Hoang Dong Nguyen [Université de Sherbrooke] Search for new biomarkers related to human brain IDH-wt cancer
Thierry Bertomeu [IRIC, Université de Montréal] Parallelized genome-wide CRISPR screens uncover chemical mechanism-of-action and gene function

18:00

Souper | Dinner
1909 Taverne Moderne

1280 Avenue des Canadiens-de-Montréal
Montréal, QC H3C 5L2
Métro Lucien-L’Allier Metro Station

MERCREDI 5 JUIN 2019 | WEDNESDAY JUNE 5, 2019

8:30 – 10:15

 Session VII –A: Invertébrés III – Salle S1-111 | Invertebrates III – Room S1-111
Modératrice | Moderator: Abigail Gerhold
Esther Verheyen 
[Simon Fraser University] Decoding nutrient sensing and metabolic rewiring in the Hipk tumor model
Patrick Laprise [CRCHU, Université Laval] Drosophila melanogaster as a model system to unravel the link between loss of epithelial cell polarity and cancer progression
Amel Chaouch [McGill University] Expression of human oncogenic mutant histone H3.3 in Drosophila melanogaster disrupts development and compromises
tissue-specific transcriptional regulation

Cédric Plutoni [IRIC, Université de Montréal] Misshapen coordinates protrusion restriction and actomyosin contractility during collective cell migration
Silvana Jananji [IRIC, Université de Montréal] Insights into the function of the scaffold, Anillin, from the analysis of ectopic nuclear filaments

8:30 – 10:15

 Session VII –B: Modèles vertébrés – Room S1-151 | Vertebrate Models – Room S1-151
Modérateur | Moderator: Vincent Archambault
Vera Gorbunova 
[University of Rochester] Anticancer mechanisms in long-lived mammals
Peng Huang [University of Calgary] Maintenance of tissue integrity by fibroblasts originated from the sclerotome
Stéphane Roy [Université de Montréal] Tissue regeneration in the axolotl (A New Era for an Old model)
Rana Amini [Max Planck Institute of Molecular Cell biology and Genetics] Investigating cell and tissue organising principles of horizontal cell lamination in the vertebrate retina
Pierre Couvineau [IRIC, Université de Montréal] Monitoring Signalling and trafficking of Neurotensin Type 1 Receptor in Animal Model using fluorescent-based methods

10:15 – 10:45

 Pause Café | Coffee Break

10:30 – 12:30

 Session présentations par affiches | Poster Session

12:30 – 14:00

 Dîner | Lunch

14:00 – 15:45

 Session VIII –A: Cellules souches – Salle S1-151 | Stem Cells – Room S1-151
Modératrice | Moderator: Julie Lessard
Michel Cayouette 
[Institut de recherches cliniques de Montréal] Regulating cell numbers in the developing nervous system
Kristin Hope [McMaster University] Uncovering post-transcriptional circuitries underlying hematopoietic stem cell function
Bill Stanford [Ottawa Hospital Research Institute] Stem cell models identify proteasome inhibition as a potential therapy for tuberous sclerosis neural but not mesenchymal
tumors

Bernhard Lehnertz [IRIC, Université de Montréal] A Genetically Encoded Human Hematopoietic Stem Cell (HSC) Reporter
Mathieu Tremblay [McGill University] A GATA3/BMP axis regulates normal and cancerous prostate stemness

14:00 – 15:45

 Session VIII –B: Biologie synthétique et ingénierie génomique – Salle S1-111 |
Synthetic Biology and Genome Engineering – Room S1-111
Modérateur | Moderator: Malcolm Whiteway
Hans-Joachim Wieden 
[University of Lethbridge] From sequence to function and back again – Structural dynamics as a designable feature and its application in precision health
Laura Simon [IRIC, Université de Montréal] Whole-genome CRISPR-Cas9 screen of the glucocorticoid response in AML identifies PLZF as an important driver of
resistance

Samuel Jacques [IRIC, Université de Montréal] A synthetic biology platform to generate and screen natural product-like chemical matter
Uri David Akavia [McGill University] Monoavidin Engineered CRISPR proteins allow increased rate of Homology Directed Repair and receptor-mediated specificity
Sophie Cardin [CHU Sainte-Justine] Synthetic human models of NUP98-KDM5A acute megakaryoblastic leukemia reveal novel disease biomarkers

15:45 – 16:00

 Pause | Break

16:00 – 17:00

 Présentations par des récipiendaires de prix – Salle S1-151 | Talks by Awardees – Room S1-151
Sylvain Moineau
 [Université Laval], récipiendaire du prix "Scientifique chevronné de Canadian Science Publishing" | "Canadian Science Publishing Senior Investigator" Awardee 
Phages and CRISPR-Cas Systems: The ongoing battle

17:00 – 17:15

 Remise de prix pour présentations par affiches – Salle S1-151| Announcement of Poster Prizes– Room S1-151 

17:15 – 17:30

 Mot de clôture– Salle S1-151 | Closing remarks – Room S1-151
Imogen Coe, Vice-Présidente de la SCBM | CSMB Vice-President