Bicarbonate Transporters and Human Diseases
M.Sc. or Ph.D.
University of Alberta
Start Date: September 1, 2018
Posted: June 7, 2018
Ion and pH homeostasis is vital for a healthy body. Bicarbonate transporters are key players in this balance. Mutated bicarbonate transporters cause renal, neurological and hematological diseases among others. Our laboratory focuses on understanding the physiology and pathophysiology associated with renal bicarbonate transporters. We use ground-breaking microscopy techniques, cell biology and biochemical approaches in both in vitro and in vivoexperiments.
Our laboratory is part of the Membrane Protein Research Group and the Department of Physiology. Candidate should have some background in human physiology, cell biology or biochemistry, be highly motivated and have excellent communication skills.
Applications should include a motivation letter, a CV, a copy of undergraduate transcripts, and two contact references. For international students, proof of English proficiency is required at the time of application.
Techniques used in Dr. Cordat’s lab: a variety of Physiology, Cell Biology and Biochemical techniques including immunoblotting, immunoprecipitations, immunofluorescence coupled with confocal microscopy, primary and immortalized cell culture and electrophysiological approaches.
Keywords: renal physiology, membrane proteins, bicarbonate transporters, claudins, polarized epithelium, collecting duct, acid-base homeostasis, ion homeostasis, paracellular and transcelllar transport, cell biology.
Contact: Dr. Emmanuelle Cordat, Department of Physiology, University of Alberta, Edmonton, Canada.