First report of the House of Commons Science and Research Committee

On June 6, the new House of Commons Standing Committee on Science and Research tabled its first ever report, as part of its study on “Successes, Challenges and Opportunities for Science in Canada”. The Canadian Society for Molecular Biosciences (CSMB) was one of sixteen organizations that submitted a written submission as part of the consultations. The Committee held meetings over the course of three months, which CSMB closely followed, hearing from science and research organizations, post-secondary institutions, companies and government departments.

CSMB welcomes all 13 of the recommendations made to government, and is pleased that two of our recommendations were specifically referenced in the report:

  • That the government increase investment in science and discovery research by 25%; and
  • That the government increase its investment in the Research Support Fund, over four years, to an additional $478 million.

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Postdoctoral Position – Biochemistry – University of Toronto

DEPARTMENT OF BIOCHEMISTRY

UNIVERSITY OF TORONTO

POSITION TITLE:                 Postdoctoral Position – Limited Term
DEPARTMENT:                    Biochemistry, Faculty of Medicine
SUPERVISOR:                      Dr. Walid A. Houry

 

OVERVIEW:

The Department of Biochemistry in the Faculty of Medicine, University of Toronto invites applications for the position of postdoctoral fellow (Limited Term) to lead biochemistry and structural biology research projects evaluating the structure and function of molecular chaperones and ATP-dependent proteases.

 

QUALIFICATIONS:

Candidates require a Ph.D. with demonstrated academic and research expertise in the field of molecular biology, protein biochemistry and biophysics, and structural biology. Candidates must have evidence of independently designing, planning, and executing experiments. Experience with X-ray and/or cryoEM approaches is a must. Experience with molecular biology, protein biophysical methods, and protein-protein interaction studies are strong assets. The candidate is expected to be leader in the lab with respect to structural biology and biochemistry-related experiments. Strong organizational, interpersonal and communication skills are required, and proven ability to work positively with others in a large, open, and highly collaborative laboratory.

 

KEY DUTIES

  • Fostering the successful completion of the existing projects that are on-going in the lab by designing, planning, and executing research experiments.
  • Contributing modern molecular and biochemical expertise directly to research programs focused on understanding the mechanism of action of chaperones and proteases.
  • Key techniques that the candidate should have expertise in include (but is not limited to): Experience in X-ray and/or cryoEM protein structure determination is a must; protein-protein interactions, small molecule-protein interaction, and drug screens would be an asset.
  • Reading published papers relevant to the experiments being performed and adapting procedures accordingly.
  • Liaising with collaborators and assisting in the compilation, analysis, and reporting of research findings to researchers within and outside of the program.
  • Assist in preparing manuscripts for submission to peer review publications/journals.
  • Assist with research proposals to be submitted to granting agencies and progress reporting.

At all times, the individual is expected to support the overall research and teaching missions of the lab.

 

CONTACT

For more information about the projects, the lab website is http://lab.walidhoury.com/

Please forward a cover letter and CV to walid.houry@utoronto.ca

 

Dr. Walid A. Houry, PhD
Professor
Department of Biochemistry, Faculty of Medicine
Department of Chemistry, Faculty of Arts and Science
University of Toronto
661 University Avenue
MaRS Centre, West Tower, Room 1612
Toronto, ON M5G 1M1

CANADA

Phone (416) 946-7141 office

FAX (416) 978-8548

 

The University of Toronto is strongly committed to diversity within its community and especially welcomes applications from racialized persons / persons of colour, women, Indigenous / Aboriginal People of North America, persons with disabilities, LGBTQ persons, and others who may contribute to the further diversification of ideas.

All qualified incumbents are encouraged to apply; however, Canadians and permanent residents will be given priority.

Postdoctoral Opportunity in Structural Biology of Membrane Proteins (uOttawa / Canada)

My laboratory at the University of Ottawa Faculty of Medicine is recruiting one postdoctoral fellow to carry out structural biology studies of integral membrane proteins. We employ an integrative approach by combining protein engineering and enzymology, crystallography, electron microscopy, live-cell imaging, and in silico bioinformatics and molecular simulation. We look for a self-motivated individual who will demonstrate passion and creativity towards characterizing the structure-function relationship of important pathological/physiological targets and thrive in a collaborative environment.

To apply, please send your CV and a letter of intent to Dr. Jyh-Yeuan (Eric) Lee: jyh-yeuan.lee@uottawa.ca. Successful candidates will be notified for interviews, at which time reference letters or writing examples will be enquired for assessment. Application will remain open until the position is filled.

Role and responsibilities: 1) develop and determine approaches for structural determination by X-ray crystallography and/or cryo-electron microscopy (cryo-EM); 2) use biophysical, biochemical, cell biology and bioinformatics methods to characterize the structure-function relationship of membrane proteins; 3) write manuscripts for publications and research proposals for grant applications; 4) supervise and/or mentor graduate and undergraduate research students; 5) take opportunities to collaborate internally or externally; 6) maintain lab instruments and reagents; 7) maintain legible and detailed lab notes.

Requirement: 1) PhD/MD/VMD/PharmD (recent or to-be doctorate graduates are highly encouraged to apply); 2) must have experience (or expertise) in large-scale protein purification (preferably membrane proteins) and macromolecular structural biology, especially in X-ray crystallography and cryo-EM (with mass spectrometry and/or confocal/super-resolution microscopy as a plus); 3) extensive experience in molecular biology and protein expression in yeast and bacteria systems (with insect or mammalian system as a plus); 4) good interpersonal skills; 5) fluency in written and spoken English (with French as a plus).

Timeline and benefits: The position will commence in 2023, and the starting date will be determined upon agreement between the candidate, the PI, and the Human Resources at uOttawa. The initial hiring aims for a length of 2 years, with the contract being renewed annually and a salary of $34,000 or more (plus benefits). Further extension will be subjected to the research performance and the funding availability.

About us:

Dr. Lee’s laboratory (https://www.leejylab.org/) focuses on the structural and functional characterizations of transporter membrane proteins that regulate cholesterol and phospholipid homeostasis, with a long-term goal to target these proteins for pharmacological and therapeutic development. We are located at the Roger Guindon Hall, the University of Ottawa medical campus, and at the heart of the Ottawa Health Sciences Centre. City of Ottawa is the capital city of Canada and situated at the border of Ontario and Québec, a bilingual city with a broad spectrum of cultural diversity, as well as inclusiveness of various international communities.

Principal Investigators in Cellular, Systems and Developmental Biology, Lunenfeld-Tanenbaum Research Institute of Sinai Health System, University of Toronto

Lunenfeld-Tanenbaum Research Institute logoPosition Title: Principal Investigators in Cellular, Systems and Developmental Biology

Location: Toronto, ON, Canada

Position Type: Faculty

Position URL: apply.interfolio.com/104159

 

Position Description

The Lunenfeld-Tanenbaum Research Institute of Sinai Health System, a University of Toronto affiliated biomedical research centre, is recruiting emerging leaders in the area of Cellular, Systems and Developmental Biology. The appointments will be for Principal Investigators (rank equivalent to Assistant Professor).

We seek applicants who will develop innovative, outstanding and independent programs in Cellular, Systems and Developmental Biology.  Research approaches include, but are not limited to, the application of functional genomics, proteomics, metabolomics, epigenomics, single-cell analytics, and tissue engineering to investigate complex systems from the molecular to organism level including humans and/or model animal systems. Topic areas encompass reproductive, developmental, and regenerative biology, cellular physiology, and network and systems biology.

The successful candidates will join the Lunenfeld-Tanenbaum Research Institute’s faculty who are internationally renowned for their work in signalling networks, cancer and developmental biology, structural biology, imaging, high throughput screening and proteomics. With numerous discoveries in basic and applied research in cancer, developmental biology, stem cell biology, diabetes, genetic disorders and women’s and infants’ health, the Lunenfeld-Tanenbaum Research Institute is committed to excellence in health research and the training of young investigators. The Institute provides a research-intensive environment with modern and innovative core facilities that include proteomics, next-generation sequencing, single cell platforms, robotics and imaging that drive technology development and are housed in the Network Biology Collaborative Centre. Sinai Health System is also the home of The Centre for Phenogenomics, a state-of-the-art national facility for mouse models.

Lunenfeld-Tanenbaum Research Institute labs engage in productive collaborations within the Institute, Sinai Health System, the larger University of Toronto community, and beyond. The University of Toronto has one of the most concentrated biomedical research communities in the world, including 9 academic hospital research institutes that are fully affiliated with the University. Toronto is a vibrant, safe and multicultural city with excellent quality of life.

Qualifications

Investigators at the Lunenfeld-Tanenbaum Research Institute are appointed to independent positions equivalent to Assistant, Associate or Full Professor, depending on experience; preference for this opportunity will be given to individuals qualifying at the level of Assistant Professor. Investigators will be cross-appointed to appropriate research or clinical department(s) at the University of Toronto.

Successful candidates will hold a PhD and/or MD degree, with postdoctoral experience and an established record of research accomplishment as demonstrated by outstanding publications, presentations at international conferences, awards and accolades, as well as strong endorsement by referees of high international standing. The successful candidates will be expected to initiate and lead innovative, independent, and externally funded, research program of the highest international calibre.

We offer competitive and generous salary and start-up packages commensurate with experience and qualifications (illustrative salary range between $140,000 and $160,000).

The Lunenfeld-Tanenbaum Research Institute and Sinai Health System are strongly committed to diversity within its community and especially welcome applications from racialized persons / persons of colour, women, Indigenous / Aboriginal People of North America, persons with disabilities, and members of sexual minority groups, and others who may contribute to the further diversification of ideas.

The Lunenfeld-Tanenbaum Research Institute and Sinai Health System recognize that scholars have varying career paths and that career interruptions due to personal circumstances can be part of an excellent academic record. Candidates are encouraged to explain any personal circumstances in order to allow for a fair assessment of their application. Search committee members have been instructed to give careful consideration to, and be sensitive to the impact of, career interruptions in their assessments.

As part of the University of Toronto and Sinai Heath System’s implementation of their Canada Research Chairs Equity, Diversity & Inclusion Action Plan, the successful candidate in this search MAY BE eligible for nomination for a CRC Tier 1 or CRC Tier 2 Chair if they self-identify as a member of the following federally designated groups, as defined by the Employment Equity Act (women, visible minorities, persons with disabilities, and Indigenous Peoples), or as trans, non-binary, or Two-Spirit. The nominee’s research area must align with the subject matter eligibility of CIHR.

Tier 2 Chairs are intended for exceptional emerging scholars. Nominees should be within ten years of receiving their PhD or MD degree.  Applicants who are more than 10 years from having earned their highest degree (and where career breaks exist, such as maternity, parental or extended sick leave, clinical training, etc.) may have their eligibility for a Tier 2 chair assessed through the program’s Tier 2 justification process.

For further Information on the federally endowed Canada research Chairs program, open to all nationalities, including eligible criteria, please consult the Canada Research Chairs website.  

 Application Instructions

Applications should include:

  1. A one-page structured summary that includes: A) a brief education/training history; B) a summary of the applicant’s most important research contributions (up to five), and C) an abstract of the research plan
  2. A cover letter
  3. A research statement highlighting the proposed research program (not exceeding 3 pages, including figures)
  4. A complete curriculum vitae
  5. Three reference letters

 

Applications should be submitted via the Interfolio website prior to June 30th, 2022.

https://apply.interfolio.com/104159

The search will remain open until a suitable candidate is identified. The earliest start date is October 1st, 2022, or a date to be mutually agreed upon.

Applicants needing additional information can contact Dr. Stephen Lye at PI_search@lunenfeld.ca. E-mailed applications will not be accepted.

COLLECTION OF EQUITY DATA

As part of your application, you will be asked to complete a brief Diversity Survey directly on the Interfolio site. This form is voluntary and any information directly related to you is confidential and cannot be accessed by the search committee. Results will be aggregated for institutional planning purposes as part of Sinai Health System’s Equity, Diversity and Inclusion initiative.

OTHER INFORMATION RELEVANT TO THE POSITION

In accordance with Institute’s policy and legislated health and safety requirements, employment is conditional upon the verification of credentials, completion of a health review, and demonstrating proof of immunity and vaccination status of vaccine-preventable diseases.

Sinai Health System is a scent sensitive environment, and all members of the community are expected to refrain from wearing or using scented products while visiting or working at the Institute. We also support a barrier-free workplace supported by the Institute’s accessibility plan, accommodation and disability management policies and procedures. Should you require accommodation at any point during the recruitment process, including accessible job postings, please contact the Lunenfeld-Tanenbaum Human Resources Department. All qualified applicants are strongly encouraged to apply; however, in accordance with Canadian immigration requirements, Canadians and permanent residents will be given priority.

Recording available: Science Policy Session with Senator Stan Kutcher – April 25, 2022

Science Policy Session with Senator Stan Kutcher
Co-hosted by the Canadian Society for Molecular Biosciences and the Canadian Association for Neuroscience

On Monday, April 25, the Canadian Society for Molecular Biosciences and the Canadian Association for Neuroscience welcomed the Honourable Senator Stan Kutcher for a session on science policy and advice.

Watch the recording here:

Key takeaways:

  • Scientists must engage in advocacy, it is an important part of their job
  • We need more scientists in Parliament.
  • In the absence of more scientists in Parliament, we need scientists and researchers to advocate on behalf of their communities, and highlight the important work they are doing.
  • We have to help politicians understand how science is part of everything we do, and how if we don’t invest in basic science, we don’t have the tools and products required to improve people’s health and lives.
  • Scientists and researchers need to be their own champions, and try to find other long-term science champions both in the House of Commons and in the Senate.
  • We need to highlight how government investments need to be in creating a “science enterprise”, so that young people will want to stay in Canada instead of going elsewhere, or being put off from doing scientific research all together.
  • It takes constant, repeated, and clear messaging. Fundamental science is a long-game, and communicating its impacts to politicians is a long-game.
  • Canada’s scientists need to trumpet their successes more. While mainstream media doesn’t have as many scientific journalists as it used to, science communicators need to step up to fill the void and to tell the story of science.

How you can get involved:

If you are interesting in trying to meet with your local Member of Parliament to speak about the important work you are doing and the support